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Transferrin receptor cluster of differentiation 71: A potential novel target for bladder cancer

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Haixiao Guo, Yuhang Gong, Haifeng Wang, Jiansong Wang, Zhao Yang, Chong Li


Cluster of differentiation 71 (CD71) is important to the proliferation of many tumors and could be a potential target for tumor diagnosis. This study aimed to investigate the level of CD71 expression in bladder cancer (BC) tissues and urine samples for initial detection of BC. Eighty-seven bladder tumor tissues and 219 urine samples were collected from patients diagnosed with BC in the Urology Department of the Second Affiliated Hospital of Kunming Medical University. Quantitative real-time reverse transcription PCR (qRT-PCR), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay were used to detect the gene and protein expression levels of CD71 in BC tissues and urine samples. Chi-square test was then carried out for analyses. Compared with non-BC samples, the expression levels of CD71 in BC tissues and urine increased significantly (P<0.050). In conclusion, CD71 was highly expressed in BC tissues and urine. Thus, the concentrations of urine CD71 could be a new target for clinical detection of BC.


bladder cancer; Cluster of Differentiation 71(CD71); Urine diagnosis

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