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Transgenic Animal Models of Bladder Cancer

VIEWS - 39 (Abstract) 32 (PDF)
Luyao Wang, Fuhan Zhang, Changyuan Yu, Zhao Yang, Chong Li

Abstract


Traditional animal models for cancer research represent an excellent experimental tool in bridging the gap between pre-clinical and clinical studies. The advances in gene transfer technologies allow the generation of transgenic animal models through the integration of the gene of interest into the animal models through gene transfer methods. Overcoming the limitations of traditional animal models, transgenic animal models are beneficial for studying carcinogenesis with respect to the genes. Besides, the utilization of transgenic animal models is also necessary for the development of novel targeted therapy. Bladder cancer (BC) is the most common cancer type worldwide and effective therapies targeting BC are urgently needed. Thus, with the delineation of molecular signatures of BC pathogenesis, the research involving transgenic animal models of BC will facilitate the development of clinical medicine, thereby improving the clinical outcome of BC patients in the future.


Keywords


Bladder cancer, Transgenic animal models, Gene transfer

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References


Siegel RL, Miller KD, Jemal A, 2020, Cancer Statistics, 2020. CA Cancer J Clin, 70:7–30.

Cumberbatch MG, Noon AP, 2019, Epidemiology, Aetiology and Screening of Bladder Cancer. Transl Androl Urol, 8:5–11.

Prasad SM, Decastro GJ, Steinberg GD, et al., 2011, Urothelial Carcinoma of the Bladder: Definition, Treatment and Future Efforts. Nat Rev Urol, 8:631–42. DOI: 10.1038/ nrurol.2011.144.

Dahm P, Gschwend JE, 2003, Malignant Non-Urothelial Neoplasms of the Urinary Bladder: A Review. Eur Urol, 44:672–81. DOI: 10.1016/s0302-2838(03)00416-0.

Kaufman DS, Shipley WU, Feldman AS, 2009, Bladder Cancer. Lancet, 374:239–49.

Dinney CP, McConkey DJ, Millikan RE, et al., 2004, Focus on Bladder Cancer. Cancer Cell, 6:111–6.

Olson B, Li Y, Lin Y, et al., 2018, Mouse Models for Cancer Immunotherapy Research. Cancer Discov, 8:1358–65.

Ding J, Xu D, Pan C, et al., 2014, Current Animal Models of Bladder Cancer: Awareness of Translatability (Review). Exp Ther Med, 8:691–9.

Weldon TE, Soloway MS, 1975, Susceptibility of Urothelium to Neoplastic Cellular Implantation. Urology, 5:824–7. DOI: 10.1016/0090-4295(75)90367-2.

Kerbel RS, Cornil I, Theodorescu D, 1991, Importance of Orthotopic Transplantation Procedures in Assessing the Effects of Transfected Genes on Human Tumor Growth and Metastasis. Cancer Metastasis Rev, 10:201–5. DOI: 10.1007/bf00050792.

Yamamoto S, Masui T, Murai T, et al., 1995, Frequent Mutations of the p53 Gene and Infrequent H-and K-ras Mutations in Urinary Bladder Carcinomas of NON/ Shi Mice Treated with N-butyl-N-(4-hydroxybutyl) Nitrosamine. Carcinogenesis, 16:2363–8. DOI: 10.1093/ carcin/16.10.2363.

Gengenbacher N, Singhal M, Augustin HG, 2017, Preclinical Mouse Solid Tumour Models: Status Quo, Challenges and Perspectives. Nat Rev Cancer, 17:751–65. DOI: 10.1038/nrc.2017.92.

Simmons D, 2008, The Use of Animal Models in Studying Genetic Disease: Transgenesis and Induced Mutation. Nat Educ, 1:70.

Tratar UL, Horvat S, Cemazar M, 2018, Transgenic Mouse Models in Cancer Research. Front Oncol, 8:268. DOI: 10.3389/fonc.2018.00268.

Gurumurthy CB, Lloyd KC, 2019, Generating Mouse Models for Biomedical Research: Technological Advances. Dis Model Mech, 12:dmm029462. DOI: 10.1242/ dmm.029462.

Grippo PJ, Sandgren EP, 2005, Modeling Pancreatic Cancer in Animals to Address Specific Hypothesis. Methods Mol Med, 103:217–43. DOI: 10.1385/1-59259-780-7:217.

Manning HC, Buck JR, Cook RS, 2016, Mouse Models of Breast Cancer: Platforms for Discovering Precision Imaging Diagnostics and Future Cancer Medicine. J Nucl Med, 57:60S–8S. DOI: 10.2967/jnumed.115.157917.

Gordon JW, Scangos GA, Plotkin DJ, et al., 1980, Genetic Transformation of Mouse Embryos by Microinjection of Purified DNA. Proc Natl Acad Sci USA, 77:7380–4. DOI: 10.1073/pnas.77.12.7380.

Brinster RL, Chen HY, Trumbauer M, et al., 1981, Somatic Expression of Herpes Thymidine Kinase in Mice Following Injection of a Fusion Gene into Eggs. Cell, 27:223–3. DOI: 10.1016/0092-8674(81)90376-7.

Costantini F, Lacy E, 1981, Introduction of a Rabbit Beta- Globin Gene into the Mouse Germ Line. Nature, 294:92–4. DOI: 10.1038/294092a0.

Brandl C, Ortiz O, Röttig B, et al., 2015, Creation of Targeted Genomic Deletions using TALEN or CRISPR/Cas Nuclease Pairs in One-Cell Mouse Embryos. FEBS Open Bio, 5:26–35. DOI: 10.1016/j.fob.2014.11.009.

Hsu PD, Lander ES, Zhang F, 2014, Development and Applications of CRISPR-Cas9 for Genome Engineering. Cell, 157:1262–78. DOI: 10.1016/j.cell.2014.05.010.

Brinster RL, Chen HY, Trumbauer ME, et al., 1985, Factors Affecting the Efficiency of Introducing Foreign DNA into Mice by Microinjecting Eggs. Proc Natl Acad Sci USA, 82:4438–42. DOI: 10.1073/pnas.82.13.4438.

Yong W, Qin L, Yong NI, 2005, Higher Efficiency of Transgenic Mouse Production Achievedby Double-Pronuclear Microinjection. Acta Lab Anim Sci Sin, 13:159–62.

Llewellyn GN, Alvarez-Carbonell D, Chateau M, et al., 2018, HIV-1 Infection of Microglial Cells in a Reconstituted Humanized Mouse Model and Identification of Compounds that Selectively Reverse HIV Latency. J Neurovirol, 24:192–203. DOI: 10.1007/s13365-017-0604-2.

Sun XY, Dong QX, Zhu J, et al., 2019, Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy. Curr Alzheimer Res, 16:710– 22. DOI: 10.2174/1567205016666190801153751.

Asimakopoulos F, Varmus HE, 2009, Cell-Specific Transduction of Prdm1-Expressing Lineages Mediated by a Receptor for Avian Leukosis Virus Subgroup B. J Virol, 83:4835–43. DOI: 10.1128/jvi.02254-08.

Price J, Turner D, Cepko C, 1987, Lineage Analysis in the Vertebrate Nervous System by Retrovirus-Mediated Gene Transfer. Proc Natl Acad Sci USA, 84:156–60.

Sweeney NP, Meng J, 2017, Delivery of Large Transgene Cassettes by Foamy Virus Vector. Sci Rep, 7: 8085. DOI: 10.1038/s41598-017-08312-3.

Han KA, Rothberg P, Kulesz-Martin M, 1990, Altered Levels of Endogenous Retrovirus-Like Sequence (VL30) RNA during Mouse Epidermal Cell Carcinogenesis. Mol Carcinog, 3:75–82. DOI: 10.1002/mc.2940030205.

Thompson S, Clarke AR, Pow AM, et al., 1989, Germ Line Transmission and Expression of a Corrected HPRT Gene Produced by Gene Targeting in Embryonic Stem Cells. Cell, 56:313–21. DOI: 10.1016/0092-8674(89)90905-7.

Ruby KM, Zheng B, 2009, Gene Targeting in a HUES Line of Human Embryonic Stem Cells via Electroporation. Stem Cells, 27:1496–506. DOI: 10.1002/stem.73.

Rust EM, Westfall MV, Samuelson LC, et al., 1997, Gene Transfer into Mouse Embryonic Stem Cell-Derived Cardiac Myocytes Mediated by Recombinant Adenovirus. In Vitro Cell Dev Biol Anim, 33:270–6. DOI: 10.1007/s11626-997- 0046-x.

Denham M, Conley BJ, Olsson F, et al., 2007, A Murine Respiratory-Inducing Niche Displays Variable Efficiency across Human and Mouse Embryonic Stem Cell Species. Am J Physiol Lung Cell Mol Physiol, 292:L1241–7. DOI: 10.1152/ajplung.00440.2006.

Baguisi A, Behboodi E, Melican DT, et al., 1999, Production of Goats by Somatic cell Nuclear Transfer. Nat Biotechnol, 17:456–61.

Zhang ZT, Pak J, Shapiro E, et al., 1999, Urothelium- Specific Expression of an Oncogene in Transgenic Mice Induced the Formation of Carcinoma in Situ and Invasive Transitional Cell Carcinoma. Cancer Res, 59:3512–7.

Madka V, Zhang Y, Li Q, et al., 2013, p53-Stabilizing Agent CP-31398 Prevents Growth and Invasion of Urothelial Cancer of the Bladder in Transgenic UPII-SV40T Mice. Neoplasia, 15:966–74. DOI: 10.1593/neo.13704.

Madka V, Mohammed A, Li Q, et al., 2014, Chemoprevention of Urothelial Cell Carcinoma Growth and Invasion by the Dual COX-LOX Inhibitor Licofelone in UPII-SV40T Transgenic Mice. Cancer Prev Res (Phila), 7:708–16. DOI: 10.1158/1940-6207.capr-14-0087.

Zhang ZT, Pak J, Huang HY, et al., 2001, Role of Ha-RAS Activation in Superficial Papillary Pathway of Urothelial Tumor Formation. Oncogene, 20:1973–80. DOI: 10.1038/ sj.onc.1204315.

Liu Z, Yokoyama NN, Blair CA, et al., 2016, High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with Approximately 240-Fold Higher Drug Concentration in Urine than Serum. Mol Cancer Ther, 15:430–8. DOI: 10.1158/1535-7163.mct- 15-0714-t.

Yang X, La Rosa FG, Genova EE, et al., 2013, Simultaneous Activation of Kras and Inactivation of p53 Induces Soft Tissue Sarcoma and Bladder Urothelial Hyperplasia. PLoS One, 8:e74809. DOI: 10.1371/journal.pone.0074809.

Hsu I, Yeh CR, Slavin S, et al., 2014, Estrogen Receptor Alpha Prevents Bladder Cancer via INPP4B Inhibited Akt Pathway In Vitro and In Vivo. Oncotarget, 5:7917–35. DOI: 10.18632/oncotarget.1421.

Ahmad I, Morton JP, Singh LB, et al., 2011, Beta-Catenin Activation Synergizes with PTEN Loss to Cause Bladder Cancer Formation. Oncogene, 30:178–89. DOI: 10.1038/ onc.2010.399.

Ahmad I, Patel R, Liu Y, et al., 2011, Ras Mutation Cooperates with Beta-Catenin Activation to Drive Bladder Tumourigenesis. Cell Death Dis, 2:e124. DOI: 10.1038/ cddis.2011.7.

Bien SA, Peters U, 2019, Moving from One to Many: Insights from the Growing List of Pleiotropic Cancer Risk Genes. Br J Cancer, 120:1087–9. DOI: 10.1038/s41416- 019-0475-9.

Nickerson ML, Dancik GM, Im KM, et al., 2014, Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer. Clin Cancer Res, 20:4935–48.

Rampetsreiter P, Casanova E, Eferl R, 2011, Genetically Modified Mouse Models of Cancer Invasion and Metastasis. Drug Discov Today Dis Models, 8:67–74. DOI: 10.1016/j. ddmod.2011.05.003.

Yamaguchi R, Perkins G, 2018, Animal Models for Studying Tumor Microenvironment (TME) and Resistance to Lymphocytic Infiltration. Cancer Biol Ther, 19:745–54. DOI: 10.1080/15384047.2018.1470722.

Platt FM, Hurst CD, Taylor CF, et al., 2009, Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer. Clin Cancer Res, 15:6008–17.

Fujimoto K, Yamada Y, Okajima E, 1992, Frequent Association of p53 Gene Mutation in Invasive Bladder Cancer. Cancer Res, 52:1393.

Lin JH, Zhao H, Sun TT, 1995, A Tissue-Specific Promoter that Can Drive a Foreign Gene to Express in the Suprabasal Urothelial Cells of Transgenic Mice. Proc Natl Acad Sci USA, 92:679–83. DOI: 10.1073/pnas.92.3.679.

Becher OJ, Holland EC, 2006, Genetically Engineered Models have Advantages over Xenografts for Preclinical Studies. Cancer Res, 66:3355–8, discussion 3358–9. DOI: 10.1158/0008-5472.can-05-3827.




DOI: http://dx.doi.org/10.18063/c+.v2i4.277

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