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The Dual Characteristics of Ten-eleven Translocation 1 in Cancer

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Chen Ge, Haiyang Wang, Haixu Chen, Wen Yue, Xinlong Yan


DNA methylation abnormalities in tumors often manifest as an increase or decrease of 5-methylcytosine at the genomic level or individual promoter sites. The mechanism of DNA demethylation by ten-eleven translocation proteins (TET) in maintaining the stability of global genome methylation level has attracted extensive attention. The biological functions of TET1-mediated hydroxymethylation differ among cancers due to tumor heterogeneity. Herein, recent updates on the effects of TET1 on tumor proliferation, migration, and invasion by altering DNA methylation levels are reviewed, and the direct and indirect roles of TET1 in activating or suppressing tumor progression are also discussed. Besides, the potential uses of DNA methylation analysis in clinical diagnosis and research of tumor microenvironment in relation to epigenetics are prospected. In conclusion, further studies about the dual characteristics of TET1 in cancer diseases are warranted to expand our understanding of the effects of DNA methylation in tumor which could be instrumental in the development of tumor treatment.


DNA methylation, Ten-eleven translocation proteins, Tumor

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