Open Journal Systems





Latest Progress on RNA Methylation Modification in Hepatocellular Carcinoma

VIEWS - 115 (Abstract) 31 (PDF)
Luo Dai, Huizhao Su, Gege Shu, Shihui Lai, Zhiqian Wang, Hongliang Dai, Bo Tang

Abstract


Hepatocellular carcinoma (HCC) is the most common malignant tumor worldwide, characterized by insidious onset as well as high incidence, recurrence, metastasis, and mortality rates. At present, there is no effective clinical treatment method except transplantation. The emergence and development of high throughput sequencing technologies in recent years has turned the epigenetics of cancer to spotlight; specifically, RNA methylation modification becomes a much discussed topic recently. RNA methylation modification plays a key role in the occurrence and development of HCC. This article reviews the relationship between different types of RNA methylation modification and HCC progression, which provides a new research direction for exploring the pathogenesis of HCC and developing new diagnostic methods and therapeutic targets.

Keywords


RNA modification, RNA methylation, Hepatocellular carcinoma

Full Text:

PDF

References


Ke S, Alemu EA, Mertens C, et al., 2015, A Majority of m6A Residues are in the Last Exons, Allowing the Potential for 3’ UTR Regulation. Genes Dev, 29:2037–53. DOI: 10.1101/ gad.269415.115.

Zhang L, Hou C, Chen C, et al., 2020, The Role of N(6)- Methyladenosine (m(6)A) Modification in the Regulation of circRNAs. Mol Cancer, 19:105.

Liu J, Sun G, Pan S, et al., 2020. The Cancer Genome Atlas (TCGA) Based m(6)A Methylation-Related Genes Predict Prognosis in Hepatocellular Carcinoma. Bioengineered, 11:759–68. DOI: 10.1080/21655979.2020.1787764.

Lin Y, Wei X, Jian Z, et al., 2020, METTL3 Expression is Associated with Glycolysis Metabolism and Sensitivity to Glycolytic Stress in Hepatocellular Carcinoma. Cancer Med, 9:2859–67. DOI: 10.1002/cam4.2918.

Li Z, Peng Y, Li J, et al., 2020, N(6)-Methyladenosine Regulates Glycolysis of Cancer Cells Through PDK4. Nat Commun, 11:2578. DOI: 10.1038/s41467-020-16306-5.

Chen SL, Liu LL, Wang CH, et al., 2020, Loss of RDM1 Enhances Hepatocellular Carcinoma Progression via p53 and Ras/Raf/ERK Pathways. Mol Oncol, 14:373–86. DOI: 10.1002/1878-0261.12593.

Lin X, Chai G, Wu Y, et al., 2019, RNA m(6)A Methylation Regulates the Epithelial Mesenchymal Transition of Cancer Cells and Translation of Snail. Nat Commun, 10:2065.

Xu H, Wang H, Zhao W, et al., 2020, SUMO1 modification of Methyltransferase-Like 3 Promotes Tumor Progression via Regulating Snail mRNA Homeostasis in Hepatocellular Carcinoma. Theranostics, 10:5671–86. DOI: 10.7150/ thno.42539.

Zuo X, Chen Z, Gao W, et al., 2020, M6A-Mediated Upregulation of LINC00958 Increases Lipogenesis and Acts as A Nanotherapeutic Target in Hepatocellular Carcinoma. J Hematol Oncol, 13:5. DOI: 10.1186/s13045-019-0839-x.

Zhang BH, Yan LN, Yang JY, 2019, Pending Role of METTL14 in Liver Cancer. Hepatobiliary Surg Nutr, 8:669–70. DOI: 10.21037/hbsn.2019.10.16.

Chen Y, Peng C, Chen J, et al., 2019, WTAP Facilitates Progression of Hepatocellular Carcinoma via m6A-HuR-Dependent Epigenetic Silencing of ETS1. Mol Cancer, 18:127. DOI: 10.1186/s12943-019-1053-8.

Zhao Y, You S, Yu YQ, et al., 2019, Decreased Nuclear Expression of FTO in Human Primary Hepatocellular Carcinoma is Associated with Poor Prognosis. Int J Clin Exp Pathol, 12:3376–83.

Li J, Zhu L, Shi Y., et al., 2019, m6A Demethylase FTO Promotes Hepatocellular Carcinoma Tumorigenesis via Mediating PKM2 Demethylation. Am J Transl Res, 11:6084–92.

Deng X, Su R, Stanford S, et al., 2018, Critical Enzymatic Functions of FTO in Obesity and Cancer. Front Endocrinol (Lausanne), 9:396. DOI: 10.3389/fendo.2018.00396.

Su R, Dong L, Li C, et al., 2018, R-2HG Exhibits Anti- Tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell, 172:90–105e23.

Tang B, Yang Y, Kang M, et al., 2020, m(6)A Demethylase ALKBH5 Inhibits Pancreatic Cancer Tumorigenesis by Decreasing WIF-1 RNA Methylation and Mediating Wnt Signaling. Mol Cancer, 19:3. DOI: 10.1186/s12943-019- 1128-6.

Wang X, Lu Z, Gomez A, et al., 2014, N6-Methyladenosine- Dependent Regulation of Messenger RNA Stability. Nature, 505:117–20.

Zhou Y, Yin Z, Hou B, et al., 2019, Expression Profiles and Prognostic Significance of RNA N6-Methyladenosine- Related Genes in Patients with Hepatocellular Carcinoma: Evidence from Independent Datasets. Cancer Manag Res, 11:3921–31. DOI: 10.2147/cmar.s191565.

Huang H, Bai Y, Lu X, et al., 2020, N6-Methyladenosine Associated Prognostic Model in Hepatocellular Carcinoma. Ann Transl Med, 8:633. DOI: 10.21037/atm-20-2894.

Qu N, Qin,S, Zhang X, et al., 2020, Multiple m(6)A RNA Methylation Modulators Promote the Malignant Progression of Hepatocellular Carcinoma and Affect its Clinical Prognosis. BMC Cancer, 20:165. DOI: 10.21203/ rs.2.17504/v3.

Hou J, Zhang H, Liu J, et al., 2019, YTHDF2 Reduction Fuels Inflammation and Vascular Abnormalization in Hepatocellular Carcinoma. Mol Cancer, 18:163.

Zhong L, Liao D, Zhang M, et al., 2019, YTHDF2 Suppresses Cell Proliferation and Growth via Destabilizing the EGFR mRNA in Hepatocellular Carcinoma. Cancer Lett, 442:252–61. DOI: 10.1016/j.canlet.2018.11.006.

Yang Z, Li J, Feng G, et al., 2017, MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3’-Untranslated mRNA Region of the N(6)- Methyladenosine Binding YTH Domain Family 2 Protein. J Biol Chem, 292:3614–23. DOI: 10.1074/jbc.m116.749689.

Han D, Liu J, Chen C, et al., 2019, Anti-Tumour Immunity Controlled Through mRNA m(6)A Methylation and YTHDF1 in Dendritic Cells. Nature, 566:270–4. DOI: 10.1038/s41586-019-0916-x.

He Y, Yu X Li J, et al., 2020, Role of m5C-Related Regulatory Genes in the Diagnosis and Prognosis of Hepatocellular Carcinoma. Am J Transl Res, 12:912–22.

Yang X, Yang Y, Sun BF, et al., 2017, 5-Methylcytosine Promotes mRNA Export-NSUN2 as the Methyltransferase and ALYREF as an m(5)C Reader. Cell Res, 27:606–25.

Zhang Q, Zheng Q, Yu X, et al., 2020, Overview of Distinct 5-Methylcytosine Profiles of Messenger RNA in Human Hepatocellular Carcinoma and Paired Adjacent Non-Tumor Tissues. J Transl Med, 18:245. DOI: 10.1186/s12967-020- 02417-6.

Wei L, Wang X, Lv L, et al., 2019, The Emerging Role of microRNAs and Long Noncoding RNAs in Drug Resistance of Hepatocellular Carcinoma. Mol Cancer, 18:147.

Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, et al., 2016, The Dynamic N(1)-Methyladenosine Methylome in Eukaryotic Messenger RNA. Nature, 530:441–6. DOI: 10.1038/nature16998.

Li X, Xiong X, Wang K, et al., 2016, Transcriptome- Wide Mapping Reveals Reversible and Dynamic N(1)- Methyladenosine Methylome. Nat Chem Biol, 12:311–6. DOI: 10.1038/nchembio.2040.

Li X, Xiong X, Zhang M, et al., 2017, Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear-and Mitochondrial-Encoded Transcripts. Mol Cell, 68:993– 1005.e9. DOI: 10.1016/j.molcel.2017.10.019.

Wang Q, Wang G, Wang Y, et al., 2018, Association of AlkB Homolog 3 Expression with Tumor Recurrence and Unfavorable Prognosis in Hepatocellular Carcinoma. J Gastroenterol Hepatol, 33:1617–25. DOI: 10.1111/jgh.14117.

Liu F, Clark W, Luo G, et al., 2016, ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell, 167:816– 28.e16.

Sloan KE, Warda AS, Sharma S, et al., 2017, Tuning the Ribosome: The Influence of rRNA Modification on Eukaryotic Ribosome Biogenesis and Function. RNA Biol, 14:1138–52. DOI: 10.1080/15476286.2016.1259781.

van Tran N, Ernst FG, Hawley BR, et al., 2019, The Human 18S rRNA m6A Methyltransferase METTL5 is Stabilized by TRMT112. Nucleic Acids Res, 47:7719–33. DOI: 10.1093/nar/gkz619.

Ma H, Wang X, Cai J, et al., 2019, N(6-)Methyladenosine Methyltransferase ZCCHC4 Mediates Ribosomal RNA Methylation. Nat Chem Biol, 15:88–94. DOI: 10.1038/ s41589-018-0184-3.

Ni X, Lin Z, Dai S, et al., 2020, Screening and Verification of microRNA Promoter Methylation Sites in Hepatocellular Carcinoma. J Cell Biochem, 121:3626–41.

Wu WR, Sun H, Zhang R, et al., 2016, Methylation- Associated Silencing of miR-200b Facilitates Human Hepatocellular Carcinoma Progression by Directly Targeting BMI1. Oncotarget, 7:18684–93. DOI: 10.18632/ oncotarget.7629.

Tsai SC, Lin CC, Shih TC, et al., 2017, The miR-200b- ZEB1 Circuit Regulates Diverse Stemness of Human Hepatocellular Carcinoma. Mol Carcinog, 56:2035–47. DOI: 10.1002/mc.22657.

Zhang PP, Wang XL, Zhao W, et al., 2014, DNA Methylation- Mediated Repression of miR-941 Enhances Lysine (K)- Specific Demethylase 6B Expression in Hepatoma Cells. J Biol Chem, 289:24724–35. DOI: 10.1074/jbc.m114.567818.

Chen S, Pu J, Bai J, et al., 2018, EZH2 Promotes Hepatocellular Carcinoma Progression through Modulating miR-22/Galectin-9 Axis. J Exp Clin Cancer Res, 37:3. DOI: 10.1186/s13046-017-0670-6.

Anwar SL, Krech T, Hasemeier B, et al., 2017, Hsa-Mir-183 is Frequently Methylated and Related to Poor Survival in Human Hepatocellular Carcinoma. World J Gastroenterol, 23:1568–75. DOI: 10.3748/wjg.v23.i9.1568.

Chen Z, Wang X, Liu R, et al., 2017, KDM4B-Mediated Epigenetic Silencing of miRNA-615-5p Augments RAB24 to Facilitate Malignancy of Hepatoma Cells. Oncotarget, 8:17712–25. DOI: 10.18632/oncotarget.10832.

Yu Q, Xiang L, Yin L, et al., 2017, Loss-of-Function of miR-142 by Hypermethylation Promotes TGF-Beta- Mediated Tumour Growth and Metastasis in Hepatocellular Carcinoma. Cell Prolif, 50:e12384. DOI: 10.1111/ cpr.12384.

Gu Y, Wei X, Sun Y, et al., 2019, miR-192-5p Silencing by Genetic Aberrations is a Key Event in Hepatocellular Carcinomas with Cancer Stem Cell Features. Cancer Res, 79:941–53. DOI: 10.1158/0008-5472.can-18-1675.

Xiao J, Liu Y, Wu F, et al., 2020, miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells. Mol Ther, 28:587–98. DOI: 10.1016/j.ymthe.2019.11.021.

Anwar SL, Albat C, Krech T, et al., 2013, Concordant Hypermethylation of Intergenic microRNA Genes in Human Hepatocellular Carcinoma as New Diagnostic and Prognostic Marker. Int J Cancer, 133:660–70. DOI: 10.1002/ijc.28068.

Rui T, Xu S, Zhang X, et al., 2020, The Chromosome 19 microRNA Cluster, Regulated by Promoter Hypomethylation, is Associated with Tumour Burden and Poor Prognosis in Patients with Hepatocellular Carcinoma. J Cell Physiol, 235:6103–12. DOI: 10.1002/jcp.29538.

Zhang Y, Tang B, Song J, et al., 2019, Lnc-PDZD7 Contributes to Stemness Properties and Chemosensitivity in Hepatocellular Carcinoma through EZH2-Mediated ATOH8 Transcriptional Repression. J Exp Clin Cancer Res, 38:92. DOI: 10.1186/s13046-019-1106-2.

Schultheiss CS, Laggai S, Czepukojc B, et al., 2017, The Long Non-Coding RNA H19 Suppresses Carcinogenesis and Chemoresistance in Hepatocellular Carcinoma. Cell Stress, 1:37–54. DOI: 10.15698/cst2017.10.105.

Wu DM, Zheng ZH, Zhang YB, et al., 2019, Down-Regulated lncRNA DLX6-AS1 Inhibits Tumorigenesis through STAT3 Signaling Pathway by Suppressing CADM1 Promoter Methylation in Liver Cancer Stem Cells. J Exp Clin Cancer Res, 38:237. DOI: 10.1186/s13046-019-1239-3.

Xu F, Li CH, Wong CH, et al., 2019, Genome-Wide Screening and Functional Analysis Identifies Tumor Suppressor Long Noncoding RNAs Epigenetically Silenced in Hepatocellular Carcinoma. Cancer Res, 79:1305–17. DOI: 10.1158/0008-5472.can-18-1659.

Guo T, Gong C, Wu P, et al., 2020, LINC00662 Promotes Hepatocellular Carcinoma Progression via Altering Genomic Methylation Profiles. Cell Death Differ, 27:2191– 205. DOI: 10.1038/s41418-020-0494-3.

Wang Y, Hu Y, Wu G, et al., 2017, Long Noncoding RNA PCAT-14 Induces Proliferation and Invasion by Hepatocellular Carcinoma Cells by Inducing Methylation of miR-372. Oncotarget, 8:34429–41. DOI: 10.18632/ oncotarget.16260.

Cheng D, Deng J, Zhang B, et al., 2018, LncRNA HOTAIR Epigenetically Suppresses miR-122 Expression in Hepatocellular Carcinoma via DNA Methylation. EBioMedicine, 36:159–70. DOI: 10.1016/j. ebiom.2018.08.055.

Zhang L, Niu H, Ma J, et al., 2019, The Molecular Mechanism of LncRNA34a-Mediated Regulation of Bone Metastasis in Hepatocellular Carcinoma. Mol Cancer, 18:120.




DOI: http://dx.doi.org/10.18063/c+.v2i2.292

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Dai, et al.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recent Articles | About Journal | For Author | Fees | About Whioce

Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.