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Latest Progress on RNA Methylation Modification in Hepatocellular Carcinoma

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Luo Dai, Huizhao Su, Gege Shu, Shihui Lai, Zhiqian Wang, Hongliang Dai, Bo Tang


Hepatocellular carcinoma (HCC) is the most common malignant tumor worldwide, characterized by insidious onset as well as high incidence, recurrence, metastasis, and mortality rates. At present, there is no effective clinical treatment method except transplantation. The emergence and development of high throughput sequencing technologies in recent years has turned the epigenetics of cancer to spotlight; specifically, RNA methylation modification becomes a much discussed topic recently. RNA methylation modification plays a key role in the occurrence and development of HCC. This article reviews the relationship between different types of RNA methylation modification and HCC progression, which provides a new research direction for exploring the pathogenesis of HCC and developing new diagnostic methods and therapeutic targets.


RNA modification, RNA methylation, Hepatocellular carcinoma

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