Open Journal Systems





Association of Repeatedly Heated Oil-Induced Hepatic Fat Accumulation and Development of Cancer: A Commentary

VIEWS - 69 (Abstract) 14 (PDF)
Kashif Hussain, Afshan Siddiq, Zara Naz, Gul Ambreen

Abstract


This commentary refers to our recently published article “Association of long-term consumption of repeatedly heated mix vegetable oils (RHMVO) in different doses and hepatic toxicity through fat accumulation.” As highlighted in this article, long-term intake of RHMVO leads to fat accumulation in hepatocytes, oxidative stress, and lipid peroxidation. Several studies have illustrated the negative effect of RHMVO on human health. In this commentary, we considered other recent evidence reporting the carcinogenic and mutagenic potential of RHMVO. Furthermore, we emphasized the unique and easy to perform parameters to measure oxidative stress, lipid peroxidation, fat accumulation, and increased inflammation in hepatocytes to identify progression toward hepatic carcinoma. Our commentary is also intended to further highlight the necessity of developing food policies and regularity bodies as an approach to minimize the increasing trend of cancer incidence.

Keywords


Edible oils, Repeated heating, Oxidative stress, Thermal oxidation

Full Text:

PDF

References


Ambreen G, Siddiq A, Hussain K, 2020, Association of Long-term Consumption of Repeatedly Heated Mix Vegetable Oils in Different doses and Hepatic Toxicity through fat Accumulation. Lipids Health Dis, 2020:1–9.

Vašková H, Bučková M, 2015, Thermal Degradation of Vegetable Oils: Spectroscopic Measurement and Analysis. Proc Eng, 100:630–5.

Sommerfeld M, 1983, Trans Unsaturated Fatty Acids in Natural Products and Processed Foods. Prog Lipid Res, 22:221.

Niu SL, Mitchell DC, Litman BJ, 2005, Trans Fatty Acid Derived Phospholipids Show Increased Membrane Cholesterol and Reduced Receptor Activation as Compared to their Cis Analogs. Biochemistry, 44:4458–65.

Sun Q, Ma J, Campos H, et al., 2007, A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease. Circulation, 115:1858–65.

Adams L, Angulo P, 2005, Recent Concepts in Non-alcoholic Fatty Liver Disease. Diabetic Med, 22:1129–33.

Koumbi L, 2017, Dietary Factors can Protect against Liver Cancer Development. World J Hepatol, 9:119.

Nakai A, Oya A, Kobe H, et al., 2000, Changes in Maternal Lipid Peroxidation Levels and Antioxidant Enzymatic Activities before and after Delivery. J Nippon Med Sch, 67:434–9.

Spiteller G, 2007, The Important Role of Lipid Peroxidation Processes in Aging and Age Dependent Diseases. Mol Biotechnol, 37:5–12.

Halliwell B, Gutteridge JM, 2015, Free Radicals in Biology and Medicine. Oxford, USA: University Press.

Ighodaro O, Akinloye O, 2018, First Line Defence Antioxidants-superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPX): Their Fundamental Role in the Entire Antioxidant Defence Grid. Alexandria J Med, 54:287–93.

Brown DA, 2006, Lipid Rafts, Detergent-resistant Membranes, and Raft Targeting Signals. Physiology, 21:430–9.

Gertz C, Stier RF, 2013, 7th International Symposium on Deep-Fat Frying, San Francisco, CA (USA): Recommendations to Enhance Frying. Eur J Lipid Sci Technol, 115:589–90.

Cam A, Oyirifi AB, Liu Y, et al., 2019, Thermally Abused Frying Oil Potentiates Metastasis to Lung in a Murine Model of Late-stage Breast Cancer. Cancer Prevent Res, 12:201–10.

Ganesan K, Sukalingam K, Xu B, 2019, Impact of Consumption of Repeatedly Heated Cooking Oils on the Incidence of Various Cancers-a Critical Review. Crit Rev Food Sci Nutr, 59:488–505.

Zhao Y, Wang S, Aunan K, et al., 2006, Air Pollution and Lung Cancer Risks in China a Meta-Analysis. Sci Total Environ, 366500–13.

Kohlmeier L, Simonsen N, vant Veer P, et al., 1997, Adipose Tissue Trans Fatty Acids and Breast Cancer in the European Community Multicenter Study on Antioxidants, Mycardial Infarction, and Breast Cancer. Cancer Epidemiol Biomarkers Prev, 6:705–10.

Thampi B, Manoj G, Leelamma S, et al., 1991, Dietary Fiber and Lipid Peroxidation: Effect of Dietary Fiber on Levels of Lipids and Lipid Peroxides in High Fat Diet. Indian J Exp Biol, 29:563–7.

Srivastava S, Singh M, George J, et al., 2010, Genotoxic and Carcinogenic Risks Associated with the Dietary Consumption of Repeatedly Heated Coconut Oil. Br J Nutr, 104:1343–52.

Srivastava S, Singh M, George J, et al., 2010, Genotoxic and Carcinogenic Risks Associated with the Consumption of Repeatedly Boiled Sunflower Oil. J Agric Food Chem, 58:11179–86.

Siddiq A, Ambreen G, Hussain K, et al., 2019, Oxidative Stress and Lipid Per-oxidation with Repeatedly Heated Mix Vegetable Oils in Different doses in Comparison with Single Time Heated Vegetable Oils. Pak J Pharm Sci, 32:2099-105.

Farrell GC, Larter CZ, 2006, Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis. Hepatology, 43:S99–112.

Liu Q, Bengmark S, Qu S, 2010, The Role of Hepatic fat Accumulation in Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD). Lipids Health Dis, 9:1–9.

Marengo A, Rosso C, Bugianesi E, 2016, Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis. Ann Rev Med, 67:103–17.

Hirosumi J, Tuncman G, Chang L, et al., 2002, A Central Role for JNK in Obesity and Insulin Resistance. Nature, 420:333–6.

Hodge DR, Hurt EM, Farrar WL, 2005, The Role of IL-6 and STAT3 in Inflammation and Cancer. Eur J Cancer, 41:2502–12.




DOI: http://dx.doi.org/10.18063/c+.v2i3.293

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Hussain, et al.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recent Articles | About Journal | For Author | Fees | About Whioce

Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.