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Research Progress on the Role of Enzymes Involved in Histone Methylation in Hepatocellular Carcinoma

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Zhiqian Wang, Hongliang Dai, Huizhao Su, Shihui Lai, Luo Dai, Xiaomeng Liu, Yan Wang, Gege Shu, Bo Tang, Yang Li


Abnormal histone modification plays an important role in the occurrence and development of hepatocellular carcinoma (HCC). As an important histone modification pattern, histone methylation is closely related to the occurrence and development of HCC. In recent years, a large number of studies have shown that abnormal histone methylation is involved in the proliferation, invasion, and metastasis of HCC and is related to the prognosis of HCC patients. Enzymes associated with histone methylation play an important role in the histone methylation process. Exploration of the relationship between histone methylation and HCC, and in-depth studies on the pathogenesis of the disease would contribute to the finding of tumor markers and the development of targeted drugs, which is of great significance for the diagnosis, treatment, and prognosis of patients with HCC. This review summarizes the research progress regarding the enzymes involved in histone methylation in HCC.


Histone methylase, Histone demethylase, Hepatocellular carcinoma

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