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Research Progress on Anti-angiogenesis Drugs in Hepatocellular Carcinoma

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Yihui Yang, Liwen Ren, Hong Yang, Binbin Ge, Wan Li, Yumin Wang, Hongquan Wang, Guanhua Du, Bo Tang, Jinhua Wang


Primary liver cancer is the sixth most prevalent cancer worldwide and ranked in third for cancer-related mortality rate. Hepatocellular carcinoma (HCC) accounts for about 90% of all primary liver cancers. High vascularization of HCC implies the significance of angiogenesis in the development and pathogenesis of HCC. Several angiogenic pathways have been identified as being dysregulated in HCC, highlighting potential therapeutic targets for the treatment of HCC. In 2007, sorafenib was approved as the standard first-line treatment for advanced HCC, catapulting the therapeutic approach of HCC into the avenue of targeted therapy. In recent years, the approval of several novel targeted drugs and the progress in combination of immunotherapy and targeted therapies provide more alternatives for the treatment of HCC. The progress of anti-angiogenesis therapies in HCC over the past few decades is reviewed and the future prospect of anti-angiogenesis therapy for HCC is also discussed.


Hepatocellular carcinoma, Anti-angiogenesis, Targeted therapy, Combination treatment, Research progress

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