2019

Vol 1, No.2 CANCER+ (Published)

Table of Contents

Review Articles

by BB Xiong, JS Zhang, HF Wang, YG Zuo, JS Wang
84 Views, 40 PDF Downloads
Since the researchers discovered ferroptosis in 2012, they have conducted in-depth research and exploration on the mechanism of ferroptosis and its role in tumor evolution. ferroptosis is a new type of death that is different from apoptosis and necrosis. It is mainly dependent on the cell death caused by the increase of iron and lipid oxygen in the cell and the imbalance of redox homeostasis. After the development of urinary tumors in the middle and late stage, most patients have poor surgical results. Chemotherapy is usually given after surgery. However, some tumor cells are currently resistant to chemotherapy drugs. Therefore, the occurrence of ferroptosis increases a new idea in the treatment of urinary tumors. The purpose of this review is to outline the knowledge of ferroptosis mechanisms and regulation, its role in the growth and proliferation of urinary tumor cells, and to provide new strategies for the treatment of urological tumor diseases.
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Review Articles

by Chong Li, Xue Tan, Fangjing Fan, Xu Zhang, Zhao Yang, Meiqing Wang
62 Views, 36 PDF Downloads
Bladder cancer refers to malignant tumors that originate in the bladder mucosa. Globally, bladder cancer is the ninth most common malignant tumor and the second most common urinary tumor. Recently, the search for highly sensitive, specific, non-invasive, convenient, quick, and economical bladder cancer diagnosis and follow-up methods becomes a research challenge in the fields of basic medicine, oncology, and urology. This article covers the current status of national and international research on the diagnosis and treatment of bladder cancer, as well as the forefront achievement from our team and international peers in basic and translational medicine research on bladder cancer. As translational medicine is the only way to achieve precision medicine, there are unprecedented opportunities in the fields of bladder cancer research and translational medical research.
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Research Articles

by Yong Liu, Xinxin Shao, Zhiyuan Shi, Quanshun Li
49 Views, 40 PDF Downloads

The codelivery of drugs and genes by stimuli-responsive nanocarriers is a promising strategy for achieving an effective cancer treatment. In this study, an adenosine triphosphate (ATP)-responsive nanosystem was constructed to codeliver doxorubicin (DOX) and p53 gene based on an ATP-triggered aptamer and polyethyleneimine (PEI). In this system, DOX interacts with the GC-rich motif of duplex formed by the aptamer and its cDNA sequence. Then, a ternary nanocomplex DOX-Duplex/PEI/p53 was constructed using cationic carrier PEI25K for facilitating the intracellular delivery and release of p53 gene and DOX. The DOX-Duplex/PEI/p53 nanocomplex was found to possess an efficient anticancer effect, which was attributed to the ability of the system to trigger cell apoptosis and meanwhile block the cell cycle at G2 phase. The favorable antiproliferative effect was found to be associated with the rapid DOX and p53 gene release in response to the intracellular ATP concentration and the synergistic effect of therapeutic drug and gene.

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Research Articles

by Haixiao Guo, Yuhang Gong, Haifeng Wang, Jiansong Wang, Zhao Yang, Chong Li
49 Views, 30 PDF Downloads

Cluster of differentiation 71 (CD71) is important to the proliferation of many tumors and could be a potential target for tumor diagnosis. This study aimed to investigate the level of CD71 expression in bladder cancer (BC) tissues and urine samples for initial detection of BC. Eighty-seven bladder tumor tissues and 219 urine samples were collected from patients diagnosed with BC in the Urology Department of the Second Affiliated Hospital of Kunming Medical University. Quantitative real-time reverse transcription PCR (qRT-PCR), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay were used to detect the gene and protein expression levels of CD71 in BC tissues and urine samples. Chi-square test was then carried out for analyses. Compared with non-BC samples, the expression levels of CD71 in BC tissues and urine increased significantly (P<0.050). In conclusion, CD71 was highly expressed in BC tissues and urine. Thus, the concentrations of urine CD71 could be a new target for clinical detection of BC.

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Commentaries

by Chong Li
46 Views, 26 PDF Downloads
Not applicable
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Reports

by Zhiyong Tan, Li Ning, Jiansong Wang, Yinglong Huang, Haifeng Wang, Yigang Zuo
54 Views, 30 PDF Downloads

Leiomyosarcomas (LMSs), malignant soft tissue tumor deriving from the mesoderm, account for <0.1% of all bladder malignancies. Conventionally, radical cystectomy with lymph node dissection has been advocated, though some series report that partial cystectomy is acceptable if a negative surgical margin is achieved. Here, we describe a 20-year-old young female presenting with LMS bladder. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a lobulated mass of 2.5 X 3.0 cm on the left lateral side of the bladder. The rest of the bladder appeared normal, with no gross pelvic lymphadenopathy. She performed with transurethral resection of bladder tumor (TURBT). She was diagnosed as LMS though histopathology and immunohistochemistry. Repeat-TURBT was implemented 30 days after the first surgery. Adjuvant chemotherapy was given (Ifosfamide 120 mg/m2 and Doxorubicin 20 mg/m2 ), and she has been doing well for 12 months of follow-up.

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