Native Thiol, Total Thiol, and Dynamic Disulfide Profile in Patients with Gastrointestinal System Cancer
Abstract
Keywords
Full Text:
Download PDFReferences
Siegel RL, Miller KD, Jemal A, 2016, Cancer Statistics, 2016. CA Cancer J Clin, 66:7–30. DOI: 10.3322/caac.21332
World Health Organization, 2020, WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All. Geneva: World Health Organization.
Weinstein JN, Collisson EA, Mills GB, et al., 2013, The Cancer Genome Atlas Pan-cancer Analysis Project. Nat Genet, 45:1113. DOI: 10.1038/ng.2764
Baykara O, 2016, Kanser Tedavisinde Güncel Yaklaşimlar. Balıkesir Sağlık Bilimleri Derg, 5:154–65.
Bjelakovic G, Nikolova D, Simonetti RG, et al., 2008. Antioxidant Supplements for Preventing GIS Cancers. Cochrane Database Syst Rev, 3:CD004183. DOI: 10.1002/14651858.cd004183.pub2
Ferlay J, Shin HR, Bray F, et al., 2010, Estimates of Worldwide Burden of Cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127:2893–917. DOI: 10.1002/ijc.25516
Moertel CG, 1978, Chemotherapy of GIS Cancer. New England Journal of Medicine. 1978;299(19):1049-52.
Sen CK, Packer L, 2000, Thiol Homeostasis and Supplements in Physical Exercise. Am J Clin Nutr, 72:653S–69. DOI: 10.1093/ajcn/72.2.653s
Eren Y, Dirik E, Neşelioğlu S, et al., 2015, Oxidative stress and decreased thiol level in patients with migraine: A cross-sectional study. Acta Neurol Belgica, 115:643–9. DOI: 10.1007/s13760-015-0427-y
Turell L, Radi R, Alvarez B, 2013, The Thiol Pool in Human Plasma: The Central Contribution of Albumin to Redox Processes. Free Radic Biol Med, 65:244–53. DOI: 10.1016/j.freeradbiomed.2013.05.050
Dickinson DA, Forman HJ, 2002, Cellular Glutathione and Thiols Metabolism. Biochem Pharmacol, 64:1019–26. DOI: 10.1016/j.clinbiochem.2014.09.026
Erel O, Neselioglu S, 2014, A Novel and Automated Assay for Thiol/Disulfide Homeostasis. Clin Biochem, 47:326–32. DOI: 10.1016/j.clinbiochem.2014.09.026
Laine J, Künstle G, Obata T, et al., 2002, Differential Regulation of Akt Kinase Isoforms by the Members of the TCL1 Oncogene Family. J Biol Chem, 277:3743–51. DOI: 10.1074/jbc.m107069200
Muthiah M, Che HL, Kalash S, et al., 2015, Formulation of Glutathione Responsive Anti-proliferative Nanoparticles from Thiolated Akt1 siRNA and Disulfide-crosslinked PEI for Efficient Anti-cancer Gene Therapy. Colloids Surf B Biointerfaces, 126:322–7. DOI: 10.1016/j.colsurfb.2014.12.022
Solakhan M, Cicek H, Orhan N, et al., 2019, Role of NT, TT and Dynamic Disulphide in the Diagnosis of the Patient with Prostate Cancer and Prostatitis. Int Braz J Urol, 45:495–502. DOI: 10.1590/s1677-5538.ibju.2018.0469
Erel Ö, Erdoğan S, 2020, Thiol-disulfide Homeostasis: An Integrated Approach with Biochemical and Clinical Aspects. Turk J Med Sci, 50:1728–38. DOI: 10.3906/sag-2003-64
Muthiah M, Che HL, Kalash S, et al., 2015, Formulation of Glutathione Responsive Anti-proliferative Nanoparticles from Thiolated Akt1 siRNA and Disulfide-crosslinked PEI for Efficient Anti-cancer Gene Therapy. Colloids Surf B Biointerfaces, 126:322–7. DOI: 10.1016/j.colsurfb.2014.12.022
Sun S, Oliveira BL, Jiménez-Osés G, et al., 2018, Radical- Mediated Thiol-Ene Strategy: Photoactivation of Thiol- Containing Drugs in Cancer Cells. Angew Chem Int Ed Engl, 57:15832–15835. DOI: 10.1002/anie.201811338
Toyokuni S, Ito F, Yamashita K, et al., 2017, Iron and Thiol Redox Signaling in Cancer: An Exquisite Balance to Escape Ferroptosis. Free Radic Biol Med, 108:610–626. DOI: 10.1016/j.freeradbiomed.2017.04.024
Bilgin B, Sendur MA, Hizal M, et al., 2019, Evaluation of Dynamic Serum Thiol-disulfide Homeostasis in Colorectal Cancer. J Oncol Sci, 5:60–4. DOI: 10.1016/j.jons.2019.08.001
Sung JJ, Ng EK, Lin JT, et al., 2011, Digestive Cancer Management in Asia: Position Statements: A Report on GI Oncology Summit in 2011. J Gastroenterol Hepatol, 27:1417–22.DOI: 10.1111/j.1440-1746.2012.07194.x
Kinnula VL, Pääkkö P, Soini Y, 2004, Antioxidant Enzymes and Redox Regulating Thiol Proteins in Malignancies of the Human Lung. FEBS Lett, 569:1–6. DOI: 10.1016/j.febslet.2004.05.045
Hizal M, Sendur MA, Bilgin B, et al., 2018, Evaluation of Dynamic Serum Thiol/Disulfide Homeostasis in Locally Advanced and Metastatic Gastric Cancer. J Oncol Sci, 4:1–4. DOI: 10.1016/j.jons.2018.01.002
Gencer S, 2009, Mide Kanserinde Matriks Metalloproteinaz (MMP) Genlerinin Ifadesi Üzerine Oksidatif Stres ve RNA Müdahalesinin Etkisi. PhD Thesis August 2009 Malatya/ Turkey.
Martinez-Useros J, Li W, Cabeza-Morales M, et al., 2017, Oxidative Stress: A New Target for Pancreatic Cancer Prognosis and Treatment. J Clin Med, 6:29. DOI: 10.3390/jcm6030029
Özdemir A, Dilli UD, Özdemir D, et al., 2019, The Level of Thiol-Disulfide on Colorectal Cancer. Anat. Clin J Med Sci, 24:137–41. DOI: 10.21673/anadoluklin.469201
DOI: http://dx.doi.org/10.18063/cp.v4i2.340
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 Çiçek, et al.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Recent Articles | About Journal | For Author | Fees | About Whioce
Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.