2022

Vol 4, No.2 CANCER PLUS (in Publishing)

Table of Contents

Research Article

by María Inés Johnson Castro, Paulina Hurtado Arenas
136 Views, 61 PDF Downloads

Objectives: To explore the relationship between sociodemographic (SD) characteristics, level of uncertainty (LU) and cancer diagnosis in the elderly. Materials and methods: The National Cancer Corporation conducted a 6-week quantitative, cross-sectional, non-probability related sample study on cancer patients over 60 years old. Merle Mishel uncertainty rating scale was used for data collection. Descriptive statistical analysis was performed using central trend measurement, and correlation analysis was conducted using Pearson correlation, analysis of variance and linear regression model. Result: 54.8% of the elderly have high LU. Education level was negatively correlated with LU (R = 0.54, P = 0.0492). The variance of 28.99% (adjusted R2, 35gl) in LU can be explained by education level. There was no statistically significant correlation with other SD characteristics. Conclusion: According to the educational characteristics of the elderly in the National Cancer Corporation, a linear regression model was established to predict LU.

PDF

Research Article

by Yanwei Zhao, Zhenxing Wang, Xizi Wang, Xiaodong Jia, Mingjun Li
125 Views, 53 PDF Downloads

The presence of drug resistance can lead to differences in treatment outcomes among patients using the same drug. Therefore, identification of key biological markers associated with drug resistance can help clinicians to quickly select the appropriate drug to prolong the survival time of patients, and it is important for drug development and detailed study of the drug’s mechanism of action. Firstly, we screened different drug resistance and sensitive cell lines in esophageal cancer cell lines to find different drug resistance related genes, and annotated these calculated drug resistance related genes into the transcriptional regulatory network we constructed. The regulatory relationships within this transcriptional regulatory network were all experimentally confirmed and further filtered by real esophageal cancer data to identify drug resistance related modules and key regulators. Thirteen drug resistance-associated modules were identified, each containing 1-6 drug resistance-associated key regulators. Among them, transcription factors SP1, has-miR-21-5p and hsa-miR-1-5p play key regulatory roles in the resistance modules of various drugs, and they regulate drug resistance-associated differentially expressed genes through one-step or multi-step regulatory relationships. Key transcription factors and miRNA in the transcriptional regulatory network that regulate drug resistance-associated genes can be used as potential biomarkers to identify drug resistance to the corresponding drugs in tumor patients.

PDF

Research Article

by Hülya Çiçek, Hanım Seval Savaş, Mustafa Yıldırım, Hüseyin Gürbüz
41 Views, 22 PDF Downloads
This study aims to evaluate the use of serum native thiol (NT), total thiol (TT), and dynamic disulfide (DD) levels as biomarkers in patients with gastrointestinal system (GIS) cancer with different cancer types by comparing with healthy controls. A total of 108 subjects consisting of68 patients with GIS cancer and 40 healthy individuals as a control group were included in the study. Serum NT, TT, and DD levels were measured by an automated method developed by Erel. There was a statistically significant difference between NT levels of GIS cancer and the control group (P = 0.001). However, there were no significant differences between male and female patients in terms of serum NT levels (P = 0.08). Similarly, no significant difference was observed when comparing serum NT levels among GIS cancer types (P = 0.886). The serum TT levels were statistically significant difference (P = 0.013) in GIS cancer, 141.82 ± 48.24 μmol/l (12.7-243.9) compare to the control group, 166.03 ± 56.23 μmol/l (12.7-326.8). When the serum TT and DD levels of the patients were compared according to gender, no significant difference was found (P = 0.243 and P = 0.362, respectively). In addition, the TT levels were not significantly difference among GIS malignancies (P = 0.765). When the patient and control groups were compared in terms of DD levels, no statistically significant difference was found (P = 0.378). In conclusion, it was determined that some parameters differ statistically between patients with GIS cancer and healthy controls. Therefore, there is a significant relationship between the thiol/disulfide balance with GIS cancer. This result suggests that oxidative stress may play a role in the development of the GIS cancer, consistent with the findings in this study, but not in terms of DD levels.
PDF

Case Report

by Wafa Ibrahim Khatri, Hitesh Rajendra Singhavi, Tahoora Sarguroh, Merene Meenu, Kantamani Bala Teja, Boman Dabur, Anil Heroor
118 Views, 48 PDF Downloads

Multiple primary malignancies are rare but early detection can be achieved with the advent of advanced imaging techniques. Diagnosis of all synchronous malignancy is vital for planning and favorable outcome. In this study, we present a case of synchronous triple primary malignancy consisting of squamous carcinoma scalp, adenocarcinoma prostate, and adenocarcinoma ascending colon with history of sigmoid colon cancer 11 years back. There were 12 possible treatment options and three alternative treatment sequences. Multidisciplinary tumor board team decided to begin the treatment with hormonal therapy (Enzalutamide/Leuprolide) for advanced metastatic prostate cancers. This was followed by simultaneous surgery consisting of wide excision of the right scalp lesion and right hemicolectomy. After a year of follow-up, patient remained disease progression free. This is the first quadruple malignancy case described in literature with the combination of scalp, prostate, and colon cancers as triple synchronous malignancy. Each cancer had its own diagnostic and treatment dilemma. Collectively, sequence of management of each cancer was also a predicament. Multidisciplinary management plays a pivotal role in the successful management of synchronous malignant tumors.

PDF